When you run DR using a multi monitor setup (2 in my case, with different resolution, expanding the desktop) the client starts to lag/freeze after a couple few minutes.
The ping itself is not affected so I think the framerate drops a lot - also because when you just move the screen or mouse you notice small freezes.
Maybe the client render engine is allocating too much of the screen. Happens with both window mode and fullscreen (on one monitor).
Using ATI 7950 card.
Resolution on main screen is 1920x1080, second one was a little bit smaller (16xx x ... something) but I turned it off at the moment.